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Humanity is being attack by monsters who came from outer space known as "Evolutionary Invasion Object" whose sole purpose is to take over the planet and destroy it, are immune to conventional weapons.
DOGOO, a supranational organization that has been behind closed doors in preparation for the attack of this monsters, has been extracting the genes of distinguished individuals through history in order to create weapons that can match the Objects, called E-Gene.
Shio Ogura, a Japanese high school student, is revealed to also be an E-Gene Holder when the soul of Oda Nobunaga awakens after she tries to rescue a friend.
Geronimo, being an E-gene holder, is capable of channeling the famous indian leader Geronimo through an AU ball and in doing so is able to use an E-gene weapon resembling the personality/abilities of the indian leader, in Geronimos's case, she is able to a summon and use a big two sided axe or also called Labrys.
